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- Will Smith as Floyd Lawton / Deadshot
- Jared Leto as Joker
- Joel Kinnaman as Rick Flag
- Jai Courtney as Digger Harkness / Captain Boomerang
- Karen Fukuhara as Tatsu Yamashiro / Katana
- Adewale Akinnuoye-Agbaje as Waylon Jones / Killer Croc