Neil deGrasse Tyson is a world famous astrophysicist, cosmologist and author. In the 2 years following Superman's debut to the world, Tyson would remain somewhat skeptical of the alien superhero, though notably less so than most others.
As Superman continues his heroic career in the 2 years following the Black Zero Event, the world continues responding to Superman and what his existence means to the world, with the media referring to it as "The Superman Question". The question sparks quite a bit of controversy worldwide, with many being quick to express their opinions.
Tyson is seen on the talk show "In the Moment", along with Vikram Gandhi, discussing "The Superman Question". While Tyson is seemingly not opposed to the alien superhero, he astutely remarks that Superman's very existence challenges humanity's sense of priority in the Universe. Tyson recalls how Copernican Heliocentrism displaced Earth and restored the Sun in the center of the known Universe, and how Darwinian Evolution established that humanity was just one among other lifeforms, instead of being special on Earth. And now, with the emergence of Superman, humanity learns that it isn't even special in the entire Universe, as there is now an alien living among them.
Vikram seemingly doesn't disagree with Tyson's points, but he himself expresses a more open-minded and optimistic view - that while humanity must understand that Superman actually coming to Earth is a paradigm shift (since humans have always created icons in their own image, thereby projecting themselves onto Superman), he speculates that maybe Superman is not in fact some sort of "Devil or Jesus character", and is instead "just a guy trying to do the right thing".
Clark himself sees these interviews on television, and is visibly dismayed at Tyson's words.
Neil deGrasse Tyson is a real world astrophysicist and plays himself in the film. He has also appeared in Superman comics to show Superman where Krypton was.