Giving Clark guidance
After hearing the extraterrestrial message transmitted by the menacing General Zod, Clark Kent seeked guidance on what to do. Father Leone likewise watched the broadcast and while watching a televised news story on the message, Clark entered the church searching for advice. Clark expressed his distrust of Zod, but voiced his doubts of humanity as well. As Clark began to leave, Leone suggested that he take a leap of faith, leaving the trust part till later.
Presiding at Clark's funeral
Two years later, Father Leone presided over Clark's funeral after the latter is seemingly killed at the hands of the monster Doomsday. Leone delivers the eulogy, containing the biblical resurrection prophecy from Isaiah 26:19.
Father Leone is exceptionally kind, calm and open-minded, notably remaining fairly calm when Kal-El revealed himself to him, and instead of personally attempting to turn the alien in to the authorities (and General Zod), he instead gave him some wise advice on what action to take. Leone keeps Clark's secret without hesitation, and shows his posthumous respect for the alien superhero by later presiding over his funeral.
- In the DC Comics universe, Father Leone is a pastor in Metropolis, who Superman confides in after Lois Lane disappears in an event dubbed The Vanishing. Leone is later revealed to be dying from cancer and enlists a "cure" from the villain Equus, which actually turns out to be a horrific biological experiment that transforms Leone into an enhanced version of Equus called Pilate.